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Noninvasive quantification of human brain antioxidant concentrations after an intravenous bolus of vitamin C

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In this study, Ascorbate (Asc) and glutathione (GSH) concentrations were non-invasively quantified using double edited 1H MRS at 4T in the occipital cortex of healthy young(age 18 – 22 years, N = 22) and elderly (age 70 – 89 years, N = 22) human subjects. Elderly subjects had a lower GSH concentration compared to younger subjects (p < 0.05). Asc concentration did not have a significant association with age. Furthermore, lactate (Lac) concentration was higher in elderly than young subjects. Lower GSH and higher Lac concentrations are indications of defective protection against oxidative damage and impaired mitochondrial respiration. The effect of age on choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) T2s was examined using short echo time STEAM spectroscopy. T2s of compounds in elderly subjects were shorter than those in young subjects. In conclusion, GSH and Asc concentrations were compared non-invasively for the first time in young versus elderly subjects.
Melissa Terpstra , Carolyn Torkelson , Uzay Emir , James S. Hodges , Susan Raatz
USDA Scientist Submission
NMR in Biomedicine 2011 June v.24 no.5
Journal Articles, USDA Authors, Peer-Reviewed
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