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Zinc Absorption Adapts to Zinc Supplementation in Postmenopausal Women

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OBJECTIVE: To determine if human Zn absorption adapts to chronic high Zn intakes. METHODS: Zn absorption was measured at 0, 8, and 16 wk in healthy postmenopausal women who consumed controlled diets with ~5 mg Zn from food, supplemented to 14 (n = 6), 32 (n = 3), or 47 (n = 3) mg Zn/d for 22 wk. Zn absorption for 1 day was determined by ⁶⁵Zn-labeling of meals and whole body scintillation counting. RESULTS: At wk 0, less Zn was absorbed from diets with 14, compared with 32 or 47 mg/d (4.6, 8.7, and 10.3 mg/d, respectively; pooled SE = 0.9; p < 0.05). These differences were not apparent at wk 8 (5.4, 5.8, 6.4; NS) and became negligible by wk 16 (5.0, 5.0, 5.1; NS). Plasma Zn concentrations were unaffected. The results are consistent with a saturation response model of Zn absorption. CONCLUSION: Within several weeks, postmenopausal women biologically adapted to absorb a relatively uniform amount of 5 mg Zn/d when controlled, Zn-supplemented diets supplied consistent Zn intakes between 14 and 47 mg/d.
Beiseigel, Jeannemarie M. , Klevay, Leslie M. , Johnson, LuAnn K. , Hunt, Janet R.
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Journal of the American College of Nutrition 2009 Apr., v. 28, no. 2
American College of Nutrition
Journal Articles, USDA Authors, Peer-Reviewed
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