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Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice

Permanent URL:
http://handle.nal.usda.gov/10113/58515
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Abstract:
Selenium (Se), an essential mineral, plays a major role in cellular redox status and may have beneficial effects on bone health. The objective of this study was to determine whether Se deficiency affect redox status and bone microarchitecture in a mouse model. Thirty-three male C57BL/6J mice, 18 wk old, were randomly assigned to 3 groups. Mice were fed either a purified, Se-deficient diet (SeDel) containing ~0.9 µg Se/kg diet, or Se-adequate diets containing ~100 µg Se/kg diet from either selenomethione (SeMet) or pinto beans (SeBean) for 4 mo. The Se concentration, glutathione peroxidase {GPx1} activity, and GPx1 mRNA in liver were lower in the SeDef group than in the SeMet or SeBean group. The femoral trabecular bone volume/total volume and trabecular number were less, whereas trabecular separation was greater in SeDel group than in either the SeMet or SeBean Broup (P <0.05). Bone structural parameters between the SeMet and SeBean groups did not differ. Furthermore, Serum concentrations of C-reactive protein, tartrate-resistant acid phosphatase, and intact parathyroid hormone were higher in SeDef group than in the other 2 groups. These findings demonstrate that Se deficiency is detrimental to bone microarchitecture by increasing bone resorption, possibly through decreasing antioxidative potential.
Author(s):
Jay J. Cao , Brian R. Gregoire , Huawei Zeng
Subject(s):
C-reactive protein , acid phosphatase , animal models , antioxidant activity , bone density , bone resorption , enzyme activity , femur , gene expression regulation , glutathione peroxidase , messenger RNA , mice , parathyroid hormone , pinto beans , restricted feeding , selenium , selenomethionine , skeletal development , trace element deficiencies
Source:
Journal of nutrition 2012 7 29 v.142
Language:
English
Year:
2012
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.