Search National Agricultural Library Digital Collections

NALDC Record Details:

Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth

Permanent URL:
Rice bran chemical profiles differ across rice varieties and have not yet been analysed for differential chemopreventive bioactivity. A diverse panel of seven rice bran varieties was analysed for growth inhibition of human colorectal cancer (CRC) cells. Inhibition varied from 0% to 99%, depending on the variety of bran used. Across varieties, total lipid content ranged 5–16%, individual fatty acids had 1.4- to 1.9-fold differences,vitamin E isoforms (a-, c-, d-tocotrienols, and tocopherols) showed 1.3- to 15.2-fold differences,and differences in c-oryzanol and total phenolics ranged between 100–275 ng/mg and 57–146 ng GAE/ mg, respectively. Spearman correlation analysis was used to identify bioactive compounds implicated in CRC cell growth inhibitory activity. Total phenolics and c-tocotrienol were positively correlated with reduced CRC cell growth (p < 0.05). Stoichiometric variation in rice bran components and differential effects on CRC viability merit further evaluation elucidate their role in dietary CRC chemoprevention.
Genevieve M Forster
bioactive properties , cell growth , colorectal neoplasms , correlation , fatty acids , lipid content , rice , rice bran , vitamin E
Food chemistry 2013 4 17 v.141
Journal Articles, USDA Authors, Peer-Reviewed
Download [PDF File]
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.