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NALDC Record Details:
Synthesis of (+)- and (-)-phaselic acid
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The syntheses of both enantiomers of phaselic acid (2-O-caffeoylmalate) are described. The previously unreported acetate-protected caffeic acid anhydride was used with appropriately protected malic acid derivatives as coupling partners to provide fully protected phaselic acid. Sequential unmasking of the protecting groups afforded phaselic acid in an acceptable overall yield.
Wayne E. Zeller
Synthetic Communications 2013 v.43 no.10
Journal Articles, USDA Authors, Peer-Reviewed
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