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Obesity reduces methionine sulfoxide reductase activity in visceral adipose tissue

Permanent URL:
http://handle.nal.usda.gov/10113/56927
File:
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Abstract:
Visceral obesity is linked to insulin resistance and cardiovascular disease. A recent genetic study indicated that the gene locus for the anti-oxidant defense enzyme methionine sulphoxide reductase A (MsrA) is positively associated with the development of visceral adiposity. This work tested the hypothesis that Msr activity is diminished in visceral fat as a result of obesity. It used two animal models of obesity, wild-type rats fed a high-fat (45% of calories from fat) diet and Zucker rats fed a 10% fat calorie diet. The data indicate that MsrA activity was selectively reduced by ? 25% in the visceral adipose, but not subcutaneous adipose or liver, of both rat models as compared to control, wild type rats receiving a 10% fat calorie diet. MsrB activity was similarly reduced only in visceral fat. The data indicate that Msr activity is reduced by obesity and may alter oxidative stress signalling of obesity.
Author(s):
Eric O. Uthus , Matthew J. Picklo Sr.
Subject(s):
adipose tissue , adiposity , animal models , diet , enzyme activity , genes , insulin resistance , lipids , liver , loci , obesity , oxidative stress , oxidoreductases , rats , signal transduction , visceral fat
Source:
Free Radical Research 2011 v.45 no.9
Language:
English
Year:
2011
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.