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Vitamin C Prevents Hypogonadal Bone Loss

Permanent URL:
http://handle.nal.usda.gov/10113/56744
Abstract:
Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. However, very few studies have evaluated a protective role of this dietary supplement on the skeleton. Here, we show that the ingestion of vitamin C prevents the low-turnover bone loss following ovariectomy in mice. We show that this prevention in areal bone mineral density and micro-CT parameters results from the stimulation of bone formation, demonstrable in vivo by histomorphometry, bone marker measurements, and quantitative PCR. Notably, the reductions in the bone formation rate, plasma osteocalcin levels, and ex vivo osteoblast gene expression 8 weeks post-ovariectomy are all returned to levels of sham-operated controls. The study establishes vitamin C as a skeletal anabolic agent.
Author(s):
Ling-Ling Zhu , Jay Cao , Merry Sun , Tony Yuen , Raymond Zhou , Jianhua Li , Yuanzhen Peng , Surinder S. Moonga , Lida Guo , Jeffrey I. Mechanick , Jameel Iqbal , Liu Peng , Harry C. Blair , Zhuan Bian , Mone Zaidi
Subject(s):
ascorbic acid , bone density , bone formation , enzymes , epidemiological studies , gene expression , ingestion , mice , osteocalcin , osteoporosis , ovariectomy , polymerase chain reaction , skeleton , vitamin supplements
Source:
Plos One 2012 v.7 no.10
Language:
English
Year:
2012
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
File:
Download [PDF File]
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.