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Listeria monocytogenes infection in pregnant guinea pigs is associated with maternal liver necrosis, a decrease in maternal serum TNF-α concentrations, and an increase in placental apoptosis

Permanent URL:
http://handle.nal.usda.gov/10113/54025
File:
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Abstract:
Stillbirths and spontaneous abortions can result when pregnant women are exposed to the food borne pathogen, Listeria monocytogenes. Fetuses and neonates account for one-third of the 2500 cases annually. The objectives were to determine the dose dependent trends of immunological and pathological effects in pregnant guinea pigs after infection with L. monocytogenes. Timed pregnant guinea pigs were treated on gestation day (gd) 35 with doses of 10(4) to 10(8) colony forming units (CFUs) and sacrificed on gd 56. Hepatic lesions were found in dams treated with ≥10(5) CFUs. Apoptosis was detected in significantly more placentas from dams treated with ≥10(6) CFUs compared to controls. Maternal serum TNF-α concentrations were significantly decreased in all dose groups compared to controls. In conclusion, increases in premature delivery, maternal hepatic effects and placental apoptosis along with a decrease in TNF-α concentrations were associated with L. monocytogenes infection in pregnant guinea pigs.
Author(s):
Irvin, Elizabeth Ann , Williams, Denita , Voss, Kenneth A. , Smith, Mary Alice
Subject(s):
Listeria monocytogenes , abortion (animals) , apoptosis , fetal death , fetus , food pathogens , guinea pigs , hepatotoxicity , infection , listeriosis , liver , maternal effect , necrosis , neonates , placenta , pregnancy , pregnant women , premature birth , transplacental transmission , tumor necrosis factor-alpha
Note:
Includes references
Source:
REPRODUCTIVE TOXICOLOGY 2008 Oct., v. 26, no. 2
Language:
English
Year:
2008
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.