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Regression-Based Multi-Trait QTL Mapping Using a Structural Equation Model

Permanent URL:
http://handle.nal.usda.gov/10113/47707
File:
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Abstract:
Quantitative trait loci (QTL) mapping often results in data on a number of traits that have well-established causal relationships. Many multi-trait QTL mapping methods that account for the correlation among multiple traits have been developed to improve the statistical power and the precision of QTL parameter estimation. However, none of these methods are capable of incorporating the causal structure among the traits. Consequently, genetic functions of the QTL may not be fully understood. Structural equation modeling (SEM) allows researchers to explicitly characterize the causal structure among the variables and to decompose effects into direct, indirect, and total effects. In this paper, we developed a multi-trait SEM method of QTL mapping that takes into account the causal relationships among traits related to grain yield. Performance of the proposed method is evaluated by simulation study and applied to data from a wheat experiment. Compared with single trait analysis and the multi-trait least-squares analysis, our multi-trait SEM improves statistical power of QTL detection and provides important insight into how QTLs regulate traits by investigating the direct, indirect, and total QTL effects. The approach also helps build biological models that more realistically reflect the complex relationships among QTL and traits and is more precise and efficient in QTL mapping than single trait analysis.
Author(s):
Mi, Xiaojuan , Eskridge, Kent , Wang, Dong , Baenziger, P. Stephen , Campbell, B. Todd , Gill, Kulvinder S. , Dweikat, Ismail , Bovaird, James
Subject(s):
Triticum aestivum , wheat , grain yield , plant genetics , quantitative trait loci , regression analysis , chromosome mapping , equations , mathematics and statistics , mathematical models , agronomic traits
Note:
Includes references
Source:
Statistical applications in genetics and molecular biology 2010 Jan., v. 9, no. 1
Language:
English
Year:
2010
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.