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Reduction of cancer risk by consumption of selenium-enriched plants: enrichment of broccoli with selenium increases the anticarcinogenic properties of broccoli

Permanent URL:
http://handle.nal.usda.gov/10113/45971
Abstract:
Plant-based diets and phytochemicals present in plants are associated with decreased risk of cancer. Brassica species, and broccoli in particular, are associated with reduced risk of several important cancers. Selenium (Se) is an essential nutrient that is covalently bound in a number of different chemical forms found in plants. Broccoli accumulates Se many-fold beyond the concentration of Se in the soil, and the chemical form of Se in broccoli is similar to the chemical form in high-Se garlic, a food with unique chemoprotective properties. Se from broccoli grown to accumulate more than 500 µg Se/g did not accumulate in rat tissues or increase glutathione peroxidase enzyme activity to the same extent as Se salts or seleno-amino acids. Se from high-Se broccoli decreased the incidence of aberrant crypts in rats with chemically induced colon cancer by more than 50%, compared with controls. Se from high-Se broccoli also decreased the incidence of mammary tumors in rats treated with 7,12-dimethylbenz(a)anthracene (DMBA) and tumor number and volume in APCmin mice. These results suggest that development of methods to increase the natural accumulation of Se in broccoli may greatly enhance its health-promoting properties.
Author(s):
Finley, J.W.
Subject(s):
neoplasms , risk reduction , nutritional intervention , plant-based foods , broccoli , enriched foods , selenium , dietary minerals , chemical structure , anticarcinogenic activity , phytochemicals , seleno amino acids , health promotion , chemoprevention , metabolism , biochemical pathways , enzyme activity , rats , animal models , colorectal neoplasms , diet therapy , nutrient intake , nutrient availability , cell growth
Format:
p. 19-26.
Note:
Includes references
Source:
Journal of medicinal food Spring 2003. v. 6 (1)
Language:
English
Year:
2003
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
File:
Download [PDF File]
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.