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Increased antioxidant capacity and inhibition of lipid peroxidation in healthy adults consuming an acai (Euterpe oleracea) fruit-based juice
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The in vitro and in vivo properties of an açai based juice blend (MonaVie Active, Salt Lake City, UT) were evaluated. Initially, a phenolic profile was determined for the beverage, and a cell-based antioxidant protection (CAP-e) assay (Honzel et al., 2008) was performed, which showed that the antioxidants in the beverage could penetrate erythrocytes and significantly protect the cells from oxidative damage in vitro (p < 0.001). Polymorphonuclear (PMN) cells exposed to the beverage showed significantly reduced formation of reactive oxygen species (ROS) and also had significantly reduced migration toward three pro-inflammatory chemoattractants. A randomized, double-blind, placebo-controlled, cross-over study was performed on the beverage using 12 healthy subjects, 19-52 years of age (Jensen et al., 2008). At both one and two hours post consumption, a statistically significant increase in antioxidant capacity within subjects was noted based upon the CAP-e assay performed on serum ((p < 0.03 and (p < 0.015). Additionally, a statistically significant decrease in serum lipid peroxidation was noted using the thiobarbituric acid reactive substances assay (TBARS) at two hours after consumption ((p < 0.01), together suggesting an in vivo antioxidant effect and, hence, bioavailability of the beverage.
Paper presented at the Second International Symposium on Human Health Effects of Fruits and Vegetables. Favhealth 2007, held October 9-13, 2007, Houston, Texas.
Acta horticulturae 2009 Aug., no. 841
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