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Molecular Identification of Aspergillus Species Collected for the Transplant-Associated Infection Surveillance Network

Abstract::: A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and β-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.
Author(s):: Balajee, S. Arunmozhi , Kano, Rui , Baddley, John W. , Moser, Stephen A. , Marr, Kieren A. , Alexander, Barbara D. , Andes, David , Kontoyiannis, Dimitrios P. , Perrone, Giancarlo , Peterson, Stephen , Brandt, Mary E. , Pappas, Peter G. , Chiller, Tom
Subject(s):: aspergillosis , Aspergillus flavus , Aspergillus niger , Aspergillus , etiology , pathogen identification , nucleotide sequences , genes , tubulin , organ transplantation , patients , human diseases , internal transcribed spacers , minimum inhibitory concentration , antimicrobial agents
Description:: Includes references
Source:: Journal of clinical microbiology JCM 2009 Oct., v. 47, no. 10
Language:: English
Year:: 2009
Publisher:: American Society for Microbiology
Collection:: Journal Articles, USDA Authors, Peer-Reviewed
File:: Download [PDF]
Rights:: Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.