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Reduced Toxicity of Fumonisin B1 in Corn Grits by Single-Screw Extrusion

Permanent URL:
http://handle.nal.usda.gov/10113/22639
File:
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Abstract:
Corn grits spiked with 30 μg/g fumonisin B1 and two batches of grits fermented with Fusarium verticillioides (batch 1 contained 33 μg/g, and batch 2 contained 48 μg/g fumonisin B1), which were extruded by a single-screw extruder with and without glucose (10%, dry weight basis) supplementation were fed to rats. Control groups were fed uncontaminated grits. Extrusion with glucose more effectively reduced fumonisin B1 concentrations of the grits (75 to 85%) than did extrusion alone (10 to 28%). With one exception, the fumonisin B1-spiked and fermented extrusion products caused moderately severe kidney lesions and reduced kidney weights, effects typically found in fumonisin-exposed rats. Lesions in rats fed the least contaminated grits (batch 1) after extrusion with 10% glucose were, however, significantly less severe and not accompanied by kidney weight changes. Therefore, extrusion with glucose supplementation is potentially useful for safely reducing the toxicity of fumonisins in corn-based products and studies to determine the optimal conditions for its use are warranted.
Author(s):
Voss, Kenneth A. , Bullerman, Lloyd B. , Bianchini, Andreia , Hanna, Milford A. , Ryu, Dojin
Subject(s):
toxicity , toxicity testing , fumonisin B1 , corn grits , extrusion , food contamination , rats , animal models , experimental diets , kidney diseases , dietary exposure , Gibberella fujikuroi
Format:
p. 2036-2041.
Note:
Includes references
Source:
Journal of food protection 2008 Oct., v. 71, no. 10
Language:
English
Year:
2008
Collection:
Journal Articles, USDA Authors, Peer-Reviewed
Rights:
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.