Search National Agricultural Library (NAL) Digital Collections
Showing item
0 of from your search.
start over
Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid
- Abstract::
- The activity of fludioxonil, a phenylpyrrole fungicide, is elevated by coapplication of the aspirin/salicylic acid metabolite, 2,5-dihydroxybenzoic acid (2,5-DHBA). Fludioxonil activity is potentiated through a mitogen-activated protein kinase (MAPK) pathway that regulates osmotic/oxidative stress-responses. 2,5-DHBA disrupts cellular GSH (reduced glutathione)/GSSG (oxidized glutathione) homeostasis, further stressing the oxidative stress-response system. This stress enhances fludioxonil activity. 2,5-DHBA treatment also prevents tolerance of MAPK mutants resistant to fludioxonil.
- Author(s):
-
Kim, Jong H. , Campbell, Bruce C. , Mahoney, Noreen , Chan, Kathleen L. , Molyneux, Russell J. , May, Gregory S.
- Subject(s):
-
pyrroles , antifungal agents , fungicides , synergism , benzoic acid , mitogen-activated protein kinase , signal transduction , glutathione , homeostasis , antioxidant activity , oxidative stress , Aspergillus fumigatus , animal pathogenic fungi , plant pathogenic fungi , Aspergillus flavus , Aspergillus parasiticus , Aspergillus niger , Aspergillus oryzae , Aspergillus nidulellus
- Description:
- Includes references
- Source:
- FEMS microbiology letters 2007 May, v. 270, no. 2
- Language:
- English
- Year:
- 2007
- Publisher:
- Oxford, UK : Blackwell Publishing Ltd
- Collection:
-
Journal Articles, USDA Authors, Peer-Reviewed
- File:
-
Download [PDF]
- Rights:
- Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
