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Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid
- The activity of fludioxonil, a phenylpyrrole fungicide, is elevated by coapplication of the aspirin/salicylic acid metabolite, 2,5-dihydroxybenzoic acid (2,5-DHBA). Fludioxonil activity is potentiated through a mitogen-activated protein kinase (MAPK) pathway that regulates osmotic/oxidative stress-responses. 2,5-DHBA disrupts cellular GSH (reduced glutathione)/GSSG (oxidized glutathione) homeostasis, further stressing the oxidative stress-response system. This stress enhances fludioxonil activity. 2,5-DHBA treatment also prevents tolerance of MAPK mutants resistant to fludioxonil.
Kim, Jong H. , Campbell, Bruce C. , Mahoney, Noreen , Chan, Kathleen L. , Molyneux, Russell J. , May, Gregory S.
pyrroles , antifungal agents , fungicides , synergism , benzoic acid , mitogen-activated protein kinase , signal transduction , glutathione , homeostasis , antioxidant activity , oxidative stress , Aspergillus fumigatus , animal pathogenic fungi , plant pathogenic fungi , Aspergillus flavus , Aspergillus parasiticus , Aspergillus niger , Aspergillus oryzae , Aspergillus nidulellus
- Includes references
- FEMS microbiology letters 2007 May, v. 270, no. 2
- Oxford, UK : Blackwell Publishing Ltd
Journal Articles, USDA Authors, Peer-Reviewed
- Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.